Metabolic research critique Essay Example | Topics and Well Written Essays - 500 words

Metabolic research critique - Essay theoretical accountAccording to the paper, there are approximately 300 accounted types of inherited metabolic diseases (IMD) and there is a round-the-clock increase and the authors of the article perceived the importance of early identification of the presence of IMD in the system of the patients. The scrap is that there is a higher percentage of diagnosis during 15 years and above than in the rootage year of life but this brook make the different since early diagnosis is important. The subjects have indications of realistic IMD undertaken (both confirmed and suspected).The research objective is stated on the last part of the background of the study. It is to be qualified to establish a gene expression signature to be able to improve detection of IMD rather than normal diagnostic techniques.The subject of the research or the tribe had been described in the methodology extendly. These 68 patients human skin fibroblast cells became the sub jects of the research after being cultured and tested for Mycoplasma infection. One criticism regarding the population can be cerebrate to the number of subjects. Based on the rules of scientific research, it is important to have a higher number of subjects to be able to improve validity.The methods used in the research had also been stated and organized clearly. This part of the paper is one of the longest and most specific part of the study with clear distinction of the fact that the paper is adept and that most of the readers are peers who can relate to the subject be and the techniques presented such as the RNA extraction, the determination of the microarrays, the gathering and analysis of the mycroarray data, and finally the PCR and sequencing analysis.In relation to the technical presentation of the methodology, the different concepts, terms and variables are defined in a manner that only the related parameters and values are given and not defined in a laymans perspective. It can be considered that